What can be done about ALS / MND ?

Based in England, in 2010, a retired group of scientists, knowing that there is a rapidly fatal disease for which there was no effective treatment, compiled an exhaustive list of everything that had been tried without any success in extending life. This resulted in a short list of hypotheses which greatly narrowed the field to be researched.

This led to the discovery of a previously little recognised antagonist which they operationally named MRCA-4 and successfully developed a molecule that suppresses it. In 2020 the FDA granted Neuralzeta Orphan Drug Designation. (#20-7955)